Related references
Note: Only part of the references are listed.Gold(III) porphyrin 1a prolongs the survival of melanoma-bearing mice and inhibits angiogenesis
Ching Tung Lum et al.
ACTA ONCOLOGICA (2011)
Bioinorganic and medicinal chemistry: aspects of gold(I)-protein complexes
Krishna P. Bhabak et al.
DALTON TRANSACTIONS (2011)
Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors
Oliver Rackham et al.
FREE RADICAL BIOLOGY AND MEDICINE (2011)
Structural and solution chemistry, protein binding and antiproliferative profiles of gold(I)/(III) complexes bearing the saccharinato ligand
Laura Maiore et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2011)
Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase
Valentina Gandin et al.
BIOCHEMICAL PHARMACOLOGY (2010)
HIV therapeutic possibilities of gold compounds
Pascaline N. Fonteh et al.
BIOMETALS (2010)
Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro
Ching Tung Lum et al.
CANCER LETTERS (2010)
A Gold(III) Porphyrin Complex with Antitumor Properties Targets the Wnt/beta-catenin Pathway
Kim Hei-Man Chow et al.
CANCER RESEARCH (2010)
Reactions of medicinally relevant gold compounds with the C-terminal motif of thioredoxin reductase elucidated by MS analysis
Alessandro Pratesi et al.
CHEMICAL COMMUNICATIONS (2010)
Gold(I) complex of N,N '-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties-potent tight-binding inhibition of thioredoxin reductase
Kun Yan et al.
CHEMICAL COMMUNICATIONS (2010)
Cyclometalated gold(III) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons
Jessie Jing Yan et al.
CHEMICAL COMMUNICATIONS (2010)
Anticancer Therapeutics That Target Selenoenzymes: Synthesis, Characterization, in vitro Cytotoxicity, and Thioredoxin Reductase Inhibition of a Series of Gold(I) Complexes Containing Hydrophilic Phosphine Ligands
Elena Vergara et al.
CHEMMEDCHEM (2010)
Metal-based drugs for malaria, trypanosomiasis and leishmaniasis: recent achievements and perspectives
Maribel Navarro et al.
DRUG DISCOVERY TODAY (2010)
Benzimidazol-2-ylidene Gold(I) Complexes Are Thioredoxin Reductase Inhibitors with Multiple Antitumor Properties
Riccardo Rubbiani et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Focus on mammalian thioredoxin reductases - Important selenoproteins with versatile functions
Elias S. J. Arner
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)
Gold complexes as potential anti-parasitic agents
Maribel Navarro
COORDINATION CHEMISTRY REVIEWS (2009)
On the medicinal chemistry of gold complexes as anticancer drugs
Ingo Ott
COORDINATION CHEMISTRY REVIEWS (2009)
Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs
Alberto Bindoli et al.
COORDINATION CHEMISTRY REVIEWS (2009)
The anti-cancer properties of gold(III) compounds with dianionic porphyrin and tetradentate ligands
Raymond Wai-Yin Sun et al.
COORDINATION CHEMISTRY REVIEWS (2009)
The tumor proteasome as a novel target for gold(III) complexes: Implications for breast cancer therapy
Vesna Milacic et al.
COORDINATION CHEMISTRY REVIEWS (2009)
Gold(III) porphyrin complex is more potent than cisplatin in inhibiting growth of nasopharyngeal carcinoma in vitro and in vivo
Yuk Fai To et al.
INTERNATIONAL JOURNAL OF CANCER (2009)
Inhibition of Selenium Metabolism in the Oral Pathogen Treponema denticola
Sarah Jackson-Rosario et al.
JOURNAL OF BACTERIOLOGY (2009)
Auranofin disrupts selenium metabolism in Clostridium difficile by forming a stable Au-Se adduct
Sarah Jackson-Rosario et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2009)
Tetra-chloro-(bis-(3,5-dimethylpyrazolyl)methane)gold(III) chloride: An HIV-1 reverse transcriptase and protease inhibitor
Pascaline N. Fonteh et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2009)
A Gold(I) Phosphine Complex Containing a Naphthalimide Ligand Functions as a TrxR Inhibiting Antiproliferative Agent and Angiogenesis Inhibitor
Ingo Ott et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
DFT investigation of the interaction between gold(I) complexes and the active site of thioredoxin reductase
James A. S. Howell
JOURNAL OF ORGANOMETALLIC CHEMISTRY (2009)
Novel gold(I) phosphine compounds inhibit HIV-1 enzymes
Pascaline Fonteh et al.
METALLOMICS (2009)
Modulation of gold(III) porphyrin 1a-induced apoptosis by mitogen-activated protein kinase signaling pathways
Ying Wang et al.
BIOCHEMICAL PHARMACOLOGY (2008)
The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation
Andrew G. Cox et al.
BIOCHEMICAL PHARMACOLOGY (2008)
A Sugar-Modified Phosphole Gold Complex with Antiproliferative Properties Acting as a Thioredoxin Reductase Inhibitor in MCF-7 Cells
Elodie Viry et al.
CHEMMEDCHEM (2008)
Water-soluble cyclodiphosphazanes: synthesis, gold(I) metal complexes and their in vitro antitumor studies
D. Suresh et al.
DALTON TRANSACTIONS (2008)
Gold(I) complexes determine apoptosis with limited oxidative stress in Jurkat T cells
Maria Pia Rigobello et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2008)
New uses for old drugs.: Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro:: Mechanistic and pharmacological implications
Anna Rosa Sannella et al.
FEBS LETTERS (2008)
Inhibition of cathepsin B by Au(I) complexes: a kinetic and computational study
Shamila S. Gunatilleke et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2008)
Tuning the Au(I)-mediated inhibition of cathepsin B through ligand substitutions
Shamila S. Gunatilleke et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2008)
Metal compounds for the treatment of parasitic diseases
Simon P. Fricker et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2008)
Synthesis, structure and cytotoxicity of triphenylphosphinegold(I) sulfanylpropenoates
Elena Barreiro et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2008)
In vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptake
Johnson J. Liu et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2008)
Gold(III) compounds as anticancer agents: Relevance of gold-protein interactions for their mechanism of action
Angela Casini et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2008)
Chemical behavior and in vitro activity of mixed phosphine gold(I) compounds on melanoma cell lines
Francesco Caruso et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Gold(I)-mediated inhibition of protein tyrosine phosphatases:: A detailed in vitro and cellular study
Divya Krishnamurthy et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Inhibition of HIV fusion with multivalent gold nanoparticles
Mary-Catherine Bowman et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Mitochondria-targeted chemotherapeutics:: The rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols
James L. Hickey et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Anti-cancer potential of gold complexes
E. R. T. Tiekink
INFLAMMOPHARMACOLOGY (2008)
Gold(III) - Dithiocarbamato complexes induce cancer cell death triggered by thioredoxin redox system inhibition and activation of ERK pathway
Daniela Saggioro et al.
CHEMISTRY & BIOLOGY (2007)
A gold(I) phosphine complex selectively induces apoptosis in breast cancer cells: Implications for anticancer therapeutics targeted to mitochondria
Oliver Rackham et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Novel gold(I) 7-azacoumarin complex:: Synthesis, structure, optical properties, and cytotoxic effects
Jose S. Casas et al.
INORGANIC CHEMISTRY (2007)
Targeting the mitochondrial cell death pathway with gold compounds
Peter J. Barnard et al.
COORDINATION CHEMISTRY REVIEWS (2007)
Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells
Christine Marzano et al.
FREE RADICAL BIOLOGY AND MEDICINE (2007)
Mitochondria are primary targets in apoptosis induced by the mixed phosphine gold species chlorotriphenylphosphine-1,3-bis(diphenylphosphino)propanegold(I) in melanoma cell lines
Francesco Caruso et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Effects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and S
Enrico Weidauer et al.
BIOLOGICAL CHEMISTRY (2007)
Cellular pharmacological properties of gold(III) porphyrin 1a, a potential anticancer drug lead
Ying Wang et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2007)
Gold(I) chloride adducts of 1,3-bis(di-2-pyridylphosphino) propane: synthesis, structural studies and antitumour activity
Anthony S. Humphreys et al.
DALTON TRANSACTIONS (2007)
Metal based drugs: from serendipity to design
Simon Paul Fricker
DALTON TRANSACTIONS (2007)
Gold(III) compounds as anticancer drugs
Chiara Gabbiani et al.
GOLD BULLETIN (2007)
A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts
Vesna Milacic et al.
CANCER RESEARCH (2006)
A gold(I) complex with a vitamin K3 derivative:: Characterization and antitumoral activity
Jose S. Casas et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2006)
Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Cι
Eda Erdogan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Sublethal concentrations of diverse gold compounds inhibit mammalian cytosolic thioredoxin reductase (TrxR1)
Yo Omata et al.
TOXICOLOGY IN VITRO (2006)
Mitochondria as therapeutic targets for cancer chemotherapy
L. Galluzzi et al.
ONCOGENE (2006)
Inhibition of lysosomal cysteine proteases by a series of Au(I) complexes: A detailed mechanistic investigation
Shamila S. Gunatilleke et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Thioredoxin reductase and cancer cell growth inhibition by organogold(III) compounds
Lars Engman et al.
ANTI-CANCER DRUGS (2006)
Gold(III) compound is a novel chemocytotoxic agent for hepatocellular carcinoma
CT Lum et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
A novel small-molecule inhibitor of protein kinase Cι blocks transformed growth of non-small-cell lung cancer cells
M Stallings-Mann et al.
CANCER RESEARCH (2006)
Proteomic characterization of the cytotoxic mechanism of gold(III) porphyrin 1a, a potential anticancer drug
Y Wang et al.
PROTEOMICS (2006)
Cationic, linear Au(I) N-heterocyclic carbene complexes: synthesis, structure and anti-mitochondrial activity
Murray V. Baker et al.
DALTON TRANSACTIONS (2006)
Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases
S Urig et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
Gold(III) porphyrin 1a induced apoptosis by mitochondrial death pathways related to reactive oxygen species
Y Wang et al.
CANCER RESEARCH (2005)
The role of p38 MAPK activation in auranofin-induced apoptosis of human promyelocytic leukaemia HL-60 cells
SJ Park et al.
BRITISH JOURNAL OF PHARMACOLOGY (2005)
A 48-week, randomized, double-blind, double-observer, placebo- controlled multicenter trial of combination methotrexate and intramuscular gold therapy in rheumatoid arthritis - Results of The METGO Study
AJ Lehman et al.
ARTHRITIS AND RHEUMATISM (2005)
Gold dithiocarbamate derivatives as potential antineoplastic agents:: Design, spectroscopic properties, and in vitro antitumor activity
L Ronconi et al.
INORGANIC CHEMISTRY (2005)
Dithiol proteins as guardians of the intracellular redox milieu in parasites: Old and new drug targets in trypanosomes and malaria-causing plasmodia
RL Krauth-Siegel et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
Mitochondrial thioredoxin reductase inhibition by gold(I) compounds and concurrent stimulation of permeability transition and release of cytochrome c
MP Rigobello et al.
BIOCHEMICAL PHARMACOLOGY (2004)
Regulation of the mammalian selenoprotein thioredoxin reductase 1 in relation to cellular phenotype, growth, and signaling events
AK Rundlöf et al.
ANTIOXIDANTS & REDOX SIGNALING (2004)
Thioredoxin reductase as a potential molecular target for anticancer agents that induce oxidative stress
DDK Smart et al.
CANCER RESEARCH (2004)
In vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins
RWY Sun et al.
CHEMBIOCHEM (2004)
Overexpression of thioredoxin reductase I regulates NF-kappa B activation
A Sakurai et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2004)
Inhibition of lysosomal cysteine proteases by chrysotherapeutic compounds: a possible mechanism for the antiarthritic activity of Au(I)
A Chircorian et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
The thioredoxin system - From science to clinic
S Gromer et al.
MEDICINAL RESEARCH REVIEWS (2004)
Toward a novel metal-based chemotherapy against tropical diseases.: 7.: Synthesis and in vitro antimalarial activity of new gold-chloroquine complexes
M Navarro et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Gold complexes inhibit mitochondrial thioredoxin reductase: consequences on mitochondrial functions
MP Rigobello et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2004)
Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine
K Anestål et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Gold compound auranofin inhibits IκB kinase (IKK) by modifying Cys-179 of IKKβ subunit
KI Jeon et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2003)
Antitumor activity of the mixed phosphine gold species chlorotriphenylphosphine-1,3-bis(diphenylphosphino)propanegold(I)
F Caruso et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
In vitro and in vivo antitumor properties of tetrakis((trishydroxy-methyl)phosphine)gold(I) chloride
N Pillarsetty et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
The Escherichia coli copper-responsive copA promoter is activated by gold
JV Stoyanov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Gold(III) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells
CM Che et al.
CHEMICAL COMMUNICATIONS (2003)
Mechanisms of cytotoxicity and antitumor activity of gold(I) phosphine complexes: the possible role of mitochondria
MJ McKeage et al.
COORDINATION CHEMISTRY REVIEWS (2002)
Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative
MP Rigobello et al.
BRITISH JOURNAL OF PHARMACOLOGY (2002)
Gold derivatives for the treatment of cancer
ERT Tiekink
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2002)
The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase
HM Alger et al.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2002)
Induction of cellular antioxidative stress genes through heterodimeric transcription factor Nrf2/small Maf by antirheumatic gold(I) compounds
K Kataoka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells
JS Modica-Napolitano et al.
ADVANCED DRUG DELIVERY REVIEWS (2001)
Molecular mechanisms of action of gold treatment in rheumatoid arthritis - an update
GR Burmester
ZEITSCHRIFT FUR RHEUMATOLOGIE (2001)
Immunomodulatory effect of gold sodium thiomalate on murine acquired immunodeficiency syndrome
K Yamaguchi et al.
MICROBIOLOGY AND IMMUNOLOGY (2001)
Role of lipophilicity in determining cellular uptake and antitumour activity of gold phosphine complexes
MJ McKeage et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2000)
Physiological functions of thioredoxin and thioredoxin reductase
ESJ Arnér et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2000)
Thiol-reactive metal compounds inhibit NF-κB activation by blocking IκB kinase
KI Jeon et al.
JOURNAL OF IMMUNOLOGY (2000)
Structure and mechanism of mammalian thioredoxin reductase:: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence
LW Zhong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Share Paper
