Journal
METALLOMICS
Volume 3, Issue 4, Pages 323-326Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0mt00081g
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Funding
- Human Frontier Science Program (Cross Disciplinary Fellowship)
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Enzymes of the cytochrome P450 superfamily can catalyse many types of oxidative transformations of a diverse substrate range. This review summarises recent work on an subset of P450s that accept their substrates in carrier protein-bound form. These examples show how the oxidative power and precision that P450s bring to natural products biosynthesis can be coupled with the advantages of using a carrier protein as a scaffold for oxidation.
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