Scavenger Receptor class B type I (SR-BI): A versatile receptor with multiple functions and actions

Scavenger receptor class B type I (SR-BI), is a physiologically relevant HDL receptor that Received 20 February 2014 mediates selective uptake of lipoprotein (HDL)-derived cholesteryl ester (CE) in vitro and in Accepted 18 March 2014 vivo. Mammalian SR-BI is a 509-amino acid, similar to 82 kDa glycoprotein that contains N- and Cterminal cytoplasmic domains, two-transmembrane domains, as well as a large Keywords: extracellular domain containing 5-6 cysteine residues and multiple sites for N-linked HDL receptor glycosylation. The size and structural characteristics of SR-BI, however, vary considerably Selective uptake among lower vertebrates and insects. Recently, significant progress has been made in Steroid hormones understanding the molecular mechanisms involved in the posttranscriptional/ posttranslational regulation of SR-BI in a tissue specific manner. The purpose of this review is to summarize the current body of knowledge about the events and molecules connected with the posttranscriptional/posttranslational regulation of SR-BI and to update the molecular and functional characteristics of the insect SR-BI orthologs. Published by Elsevier Inc.