Journal
METABOLISM-CLINICAL AND EXPERIMENTAL
Volume 57, Issue 10, Pages S11-S15Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.metabol.2008.07.006
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Funding
- NIMH NIH HHS [P50 MH058911-050004, R01 MH041256, P50 MH058911, R01 MH041256-22S1] Funding Source: Medline
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Early life experiences have powerful effects on the brain and body lasting throughout the entire life span and influencing brain function, behavior, and the risk for a number of systemic and mental disorders. Animal models of early life adversity are providing mechanistic insights, including glimpses into the fascinating world that is now called epigeneties as well as the role of naturally occurring alleles of a number of genes. These studies also provide insights into the adaptive value as well as the negative consequences, of early life stress, exposure to novelty, and poor-quality vs good-quality maternal care. Animal models begin to provide a mechanistic basis for understanding how brain development and physiological functioning is affected in children exposed to early life abuse and neglect, where there is a burgeoning literature on the consequences for physical health and emotional and cognitive development. An important goal is to identify interventions that are likely to be most effective in early life and some guidelines are provided. (C) 2008 Elsevier Inc. All rights reserved.
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