Journal
METABOLIC SYNDROME AND RELATED DISORDERS
Volume 8, Issue 4, Pages 295-305Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/met.2009.0110
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Osteoarthritis (OA) has become a major public health problem not only because of its increasing prevalence worldwide but also because of its frequent association with cardiovascular disease, the leading cause of death in industrialized countries. There is growing evidence that OA is not simply a disease related to aging or mechanical stress of joints but rather a metabolic disorder in which various interrelated lipid, metabolic, and humoral mediators contribute to the initiation and progression of the disease process. Indeed, OA has been linked not only to obesity but also to other cardiovascular risk factors, namely, diabetes, dyslipidemia, hypertension, and insulin resistance.
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