Journal
METABOLIC ENGINEERING
Volume 15, Issue -, Pages 48-54Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymben.2012.11.002
Keywords
Acetyl-CoA; Cell factory; Saccharomyces cerevisiae; alpha-Santalene
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Funding
- Firmenich
- Chalmers Foundation
- Knut and Alice Wallenberg Foundation
- European Research Council [247013]
- European Research Council (ERC) [247013] Funding Source: European Research Council (ERC)
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Production of fuels and chemicals by industrial biotechnology requires efficient, safe and flexible cell factory platforms that can be used for production of a wide range of compounds. Here we developed a platform yeast cell factory for efficient provision of acetyl-CoA that serves as precursor metabolite for a wide range of industrially interesting products. We demonstrate that the platform cell factory can be used to improve the production of alpha-santalene, a plant sesquiterpene that can be used as a perfume by four-fold. This strain would be a useful tool to produce a wide range of acetyl-CoA-derived products. (C) 2012 Elsevier Inc. All rights reserved.
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