Journal
METABOLIC ENGINEERING
Volume 14, Issue 4, Pages 289-297Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymben.2012.04.006
Keywords
Metabolic engineering; Systems biology; Biofuels; Biopolymers; Commodity chemicals; Pharmaceuticals
Categories
Funding
- Office of Naval Research Young Investigator Program
- Camille and Henry Dreyfus New Faculty Award
- DuPont Young Professor Grant
- NSF Graduate Research Fellowship
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The field of Metabolic Engineering has recently undergone a transformation that has led to a rapid expansion of the chemical palate of cells. Now, it is conceivable to produce nearly any organic molecule of interest using a cellular host. Significant advances have been made in the production of biofuels, biopolymers and precursors, pharmaceuticals and nutraceuticals, and commodity and specialty chemicals. Much of this rapid expansion in the field has been, in part, due to synergies and advances in the area of systems biology. Specifically, the availability of functional genomics, metabolomics and transcriptomics data has resulted in the potential to produce a wealth of new products, both natural and non-natural, in cellular factories. The sheer amount and diversity of this data however, means that uncovering and unlocking novel chemistries and insights is a non-obvious exercise. To address this issue, a number of computational tools and experimental approaches have been developed to help expedite the design process to create new cellular factories. This review will highlight many of the systems biology enabling technologies that have reduced the design cycle for engineered hosts, highlight major advances in the expanded diversity of products that can be synthesized, and conclude with future prospects in the field of metabolic engineering. (C) 2012 Elsevier Inc. All rights reserved.
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