Journal
METABOLIC ENGINEERING
Volume 13, Issue 1, Pages 28-37Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymben.2010.10.007
Keywords
Fatty acid; Biofuel; Diesel; Metabolic engineering; Escherichia coli
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Research towards the commercialization of fungible biofuels has received a great deal of recent interest and investment. To this end the microbial production of fatty acid-derived fuels from sustainable feed stocks is emerging as a viable option with rapid advances from both industry and academia. The manipulation of the fatty acid biosynthesis pathway, especially in Escherichia coli, has been widely studied and several approaches that increase fatty acid production have been identified. However, further advances will be required for the economic large-scale production of fatty acid-derived biofuels. Here we present an overview of fatty acid biosynthesis and its regulation in E. coli from a metabolic engineering viewpoint and offer potential approaches and considerations for the microbial over production of custom designed fatty acids for use as biofuels or in the manufacture of oleochemicals. (C) 2010 Elsevier Inc. All rights reserved.
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