Journal
METABOLIC ENGINEERING
Volume 12, Issue 4, Pages 387-391Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymben.2010.02.002
Keywords
Biofuel; High light; Nitrogen starvation; Oleaginous microalgae; Starch; Triacylglycerol
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Funding
- Science Foundation of Arizona
- Heliae Development LLC
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Many microalgae and plants have the ability to synthesize large amounts of triacylglycerol (TAG) that can be used to produce biofuels. Presently, TAG-based biofuel production is limited by the feedstock supply. Metabolic engineering of lipid synthesis pathways to overproduce TAGs in oleaginous microalgae and oil crop plants has achieved only modest success. We demonstrate that inactivation of ADP-glucose pyrophosphorylase in a Chlamydomonas strachless mutant led to a 10-fold increase in TAG, suggesting that shunting of photosynthetic carbon partitioning from starch to TAG synthesis may represent a more effective strategy than direct manipulation of the lipid synthesis pathway to overproduce TAG. (C) 2010 Elsevier Inc. All rights reserved.
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