Journal
METABOLIC BRAIN DISEASE
Volume 26, Issue 1, Pages 87-90Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11011-010-9226-6
Keywords
Cerebral ischemia; T lymphocyte; T regulatory cells; Middle cerebral artery occlusion; Stroke
Categories
Funding
- NIH [NR03521]
- Biomedical Laboratory R&D Service, Department of Veterans Affairs
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Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4(+)CD25(+)Foxp3(+) regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3(DTR) mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.
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