Journal
MEMORIAS DO INSTITUTO OSWALDO CRUZ
Volume 109, Issue 5, Pages 668-671Publisher
FUNDACO OSWALDO CRUZ
DOI: 10.1590/0074-0276140098
Keywords
eicosanoid; Anopheles; Plasmodium
Categories
Funding
- FCT [SFRH/BD/12210/2003]
- PVE (Programa Ciencia sem Fronteira FMT-HVD, Brazil)
- [POCI/SAU-IMI/59489/2004]
- [PTDC/SAU-MII/102596/2008]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/12210/2003, PTDC/SAU-MII/102596/2008] Funding Source: FCT
Ask authors/readers for more resources
Eicosanoids affect the immunity of several pathogen/insect models, but their role on the Anopheles gambiae response to Plasmodium is still unknown. Plasmodium berghei-infected mosquitoes were injected with an eicosanoid biosynthesis inhibitor, indomethacin (IN), or a substrate, arachidonic acid (AA), at day 7 or day 12 post-infection (p.i.). Salivary gland invasion was evaluated by sporozoite counts at day 21 p.i. IN promoted infection upon sporozoite release from oocysts, but inhibited infection when sporozoites were still maturing within the oocysts, as observed by a reduction in the number of sporozoites reaching the salivary glands. AA treatment had the opposite effect. We show for the first time that An. gambiae can modulate parasite survival through eicosanoids by exerting an antagonistic or agonistic effect on the parasite, depending on its stage of development.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available