Journal
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
Volume 41, Issue 6, Pages 590-596Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S106816201506014X
Keywords
sea anemones; the Kunitz-type protease inhibitors; antihistamine activity; anti-inflammatory activity
Funding
- Russian Scientific Foundation [14-25-00037]
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The anti-inflammatory activity of the HCGS 1.20 recombinant polypeptide (a Kunitz-type serine protease inhibitor from the Heteractis crispa sea anemone) was investigated. The polypeptide was shown to inhibit the histamine-induced increase in the concentration of calcium ions and the lipopolysaccharidestimulated increase in the concentration of nitric oxide (II) in macrophages. A possible mechanism of this anti-inflammatory activity of the polypeptide was discussed.
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