Journal
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
Volume 45, Issue 10, Pages 1887-1896Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/MSS.0b013e3182935fe3
Keywords
ADIPOSITY PHENOTYPE; ENERGY METABOLISM; HORMONES; FEMALE POPULATION
Categories
Funding
- Ministere Jeunesse et Sport
- Federation Francaise d'Education Physique et de Gymnastique Volontaire
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Purpose: Abdominal and lower body fat mass tissues exhibit particular metabolic profiles at rest and during exercise. However, data are missing in normal weight women during exercise. The purpose of this study was to investigate the effect of low (LA/LB) and high (HA/LB) abdominal to lower body (A/LB) fat mass ratio on metabolic and hormonal responses during exercise in premenopausal normal weight women. Methods: After preliminary testing ((V) over dotO(2max) and body composition assessment), substrate oxidation (RER, lipid, and carbohydrate oxidation rates), metabolic response (glycerol, free fatty acids, and glucose), and hormonal response (insulin, growth hormone, atrial natriuretic peptide, adrenaline, and noradrenaline) were determined during exercise (45 min at 65% of (V) over dotO(2max)) in 21 premenopausal normal weight women (10 HA/LB women vs 11 LA/LB women). Results: Waist circumference was significantly higher in HA/LB women compared with LA/LB women (P < 0.01). No difference in other anthropometric characteristics, (V) over dotO(2max), and resting blood values was observed between the two groups. LA/LB subjects exhibited greater lipid oxidation rates compared with HA/LB women during exercise (P < 0.01). This occurred with lower plasma insulin (P < 0.05) and glucose (P < 0.05) concentrations and higher plasma free fatty acids (P < 0.05), glycerol (P < 0.05), growth hormone (P < 0.05), and atrial natriuretic peptide levels (P G 0.01) during exercise in the LA/LB group compared with the HA/LB group. Conclusions: The present study demonstrated that LA/LB women exhibited an increase in whole-body lipid mobilization and use during exercise compared with HA/LB counterparts. This greater reliance on lipid as fuel metabolism during exercise could be explained by substrate availability and metabolic and hormonal responses. It appeared that LA/LB women exhibited greater metabolic flexibility during an exercise bout of 45 min at 65% of (V) over dotO(2max) on cycle ergometer.
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