Journal
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
Volume 40, Issue 3, Pages 457-461Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/mss.0b013e31815f8957
Keywords
arterial O-2 desaturation; muscle metaboreflex; intrathoracic pressures; lung : cardiovascular interactions
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We briefly summarize recent evidence pertaining to how mechanisms primarily under the control of the respiratory system-namely, arterial oxyhemoglobin desaturation, respiratory muscle work and fatigue, and cyclical fluctuations in intrathoracic pressure-may contribute to exercise limitation. Respiratory influences on cardiac output and on sympathetic vasoconstrictor activity and blood flow distribution are shown to be important determinants of performance. We also address how a compromised 02 transport exacerbates the rate of development of peripheral muscle fatigue and, in turn, precipitates central fatigue and exercise limitation.
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