Journal
MEDICINAL RESEARCH REVIEWS
Volume 32, Issue 5, Pages 1078-1091Publisher
WILEY
DOI: 10.1002/med.20238
Keywords
chemotherapy; doxorubicin; liposomes; vascular targeting; NGR; NGR-hTNF; NGR-TNF; CD13; av ss 3 integrin; isoDGR
Categories
Funding
- Associazione Italiana per la Ricerca sul Cancro (IG)
- Alleanza Contro il Cancro
- FIRB (Italy)
- Associazione Italiana Neuroblastoma fellowship
- FIRB
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Delivery and penetration of chemotherapeutic drugs into tumors are limited by a number of factors related to abnormal vasculature and altered stroma composition in neoplastic tissues. Coupling of chemotherapeutic drugs with tumor vasculature-homing peptides or administration of drugs in combination with biological agents that affect the integrity of the endothelial lining of tumor vasculature is an appealing strategy to improve drug delivery to tumor cells. Promising approaches to achieve this goal are based on the use of Asn-Gly-Arg (NGR)-containing peptides as ligands for drug delivery and of NGR-TNF, a peptide-tumor necrosis factor-a fusion protein that selectively alters drug penetration barriers and that is currently tested in a randomized Phase III trial in patients with malignant pleural mesothelioma.
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