Journal
MEDICINAL RESEARCH REVIEWS
Volume 32, Issue 5, Pages 948-967Publisher
WILEY
DOI: 10.1002/med.20229
Keywords
BRCA1; cancer stem cells; targeted therapy
Categories
Funding
- Council for Scientific and Industrial Research
Ask authors/readers for more resources
BRCA1 expression is involved in normal embryonic development, mammary stem cell differentiation, and prostate cancer development. Inactivation of BRCA1 plays an important role in cancer stem cells and also leads to the development of high-grade, basal-like tumor. This review discusses why BRCA1-defective cancer stem cells need a prospective analysis, how ER alpha could influence BRCA1-defective tumor progression, phenotype of BRCA1-defective cancers, role of BRCA1 in other cancers and finally at what perspective BRCA1-defective cancers can be targeted for better therapeutic outcome.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available