Journal
MEDICINAL RESEARCH REVIEWS
Volume 32, Issue 5, Pages 999-1025Publisher
WILEY
DOI: 10.1002/med.20231
Keywords
gelsolin; actin; apoptosis; cancer; cardiac remodeling
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Funding
- Canada Research Chair (Tier 1)
- Heart and Stroke Foundation [NA6736]
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Gelsolin, a Ca2+-regulated actin filament severing, capping, and nucleating protein, is an ubiquitous, multifunctional regulator of cell structure and metabolism. More recent data show that gelsolin can act as a transcriptional cofactor in signal transduction and its own expression and function can be influenced by epigenetic changes. Here, we review the functions of the plasma and cytoplasmic forms of gelsolin, and their manifold impacts on cancer, apoptosis, infection and inflammation, cardiac injury, pulmonary diseases, and aging. An improved understanding of the functions and regulatory mechanisms of gelsolin may lead to new considerations of this protein as a potential biomarker and/or therapeutic target.
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