Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 23, Issue 8, Pages 3714-3724Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-014-0943-y
Keywords
Antibacterial; Antitubercular; Radical scavenging activity; FRAP assay; Gatifloxacin
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Funding
- Department of Science and Technology (DST) Delhi, India
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New Cu(II) and Ni(II) complexes of acetyl coumarin derivatives with gatifloxacin were synthesized. Characterization of the complexes was carried out by elemental analysis, FT-IR, FAB-MS, electronic spectra and magnetic measurement along with thermo gravimetric studies. Thermal study reveals the absence of coordinated water molecule in case of Cu(II) complexes. All the Cu(II) complexes were found more potent antibacterial activity compared to Ni(II) complexes. The antituberculosis data have shown that copper conjugation may be advantageous in designing highly effective drugs for antitubercular therapy. These complexes were also found to be potent antioxidizing agents comprising radical scavenging capability and ferric reducing abilities.
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