Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 23, Issue 2, Pages 725-734Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-013-0671-8
Keywords
Indole-2,3-dione; 3-Methyl-1-phenyl-2-pyrazolin-5-one; Active methylene group; Antioxidant activity
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Ultrasound promoted, cerium ammonium nitrate catalyzed sustainable synthesis of spiro[indoline3,4'-pyrano[2,3-c]pyrazole] derivatives (4a-l) is reported herein. The synthesized compounds were screened for their antioxidant activities as free radical scavenging effect on diphenylpicryl hydrazine (DPPH center dot), 2,2'-azino-bis(3-ethylbenzthiazoline- 6-sulphonic acid) (ABTS(center dot+)) and nitric oxide (NO) radicals. The screened compounds showed potent scavenging activities against DPPH center dot, ABTS(center dot+) and NO radicals. In order to further extend on studies and to obtain a deep insight into structure activity relationship of this class of compounds, we designed N-substitution of indole moiety with the aim to study its antioxidant potential.
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