Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 22, Issue 4, Pages 1624-1629Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-012-0153-4
Keywords
Bisphosphonates; Phosphorous acid; Phosphorous trichloride; Microwave-assisted
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Funding
- Aurobindo Pharma Limited (APL) Research Centre
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Microwave-assisted rapid and efficient procedure for the synthesis of bisphosphonate and their libraries is described in solvent-free medium. Bisphosphonates having nitrogen and sulfur are synthesized following this new procedure. This procedure is simple and can be useful for the generation of compound libraries of a class of bone-resorptive inhibitors such as N- and N-, S- containing bisphosphonates.
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