4.2 Article

A study on the reactions of alkyl 4,6-bis(4-fluorophenyl)-2-oxocyclohex-3-ene-1-carboxylate and in vitro antioxidant activity of derivatives

Journal

MEDICINAL CHEMISTRY RESEARCH
Volume 22, Issue 6, Pages 3002-3011

Publisher

SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-012-0304-7

Keywords

4,4 '-Difluoro chalcone; Cyclohexenone; Terphenyl; Indazole; Antioxidant activity

Funding

  1. UGC

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New functionalized derivatives were prepared using alkyl 4,6-bis(4-fluorophenyl)-2-oxocyclohex-3-ene-1-carboxylate as a building block. Newly prepared compounds were well characterized using H-1 NMR, IR, and mass spectral data. All the synthesized products were screened for their antioxidant properties. Among the tested compounds, indazole derivatives exhibited noticeable DPPH radical scavenging activity and reducing power capacity in comparison with the standard Glutathione.

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