Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 21, Issue 10, Pages 2920-2925Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-011-9812-0
Keywords
Flavonoid complexes; Antioxidants; beta-Cyclodextrin, inclusion compounds; Oxidation potential
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
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Inclusion compounds of Al-quercetin and Al-catechin complexes with beta-cyclodextrin (beta CD) were investigated. The complex and the inclusion compound of quercetin are more effective DPPHaEuro cent scavengers than the corresponding catechin compounds and the inclusion does not compromise their scavenging abilities, with only a slight decrease in the EC50 values. This is in accordance with the electrochemical data, which revealed that the inclusion compounds have lower diffusion coefficients in aqueous solution than the non-included compounds. For the quercetin compounds, some spectroscopic properties were also addressed by means of UV-visible and NMR measurements in aqueous media.
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