Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 21, Issue 8, Pages 2012-2022Publisher
SPRINGER
DOI: 10.1007/s00044-011-9735-9
Keywords
Analgesic; Antimicrobial; DPPH scavenging assay; 1,3,5-Triaryl-2-pyrazoline; Molecular docking; metRS; Molecular recognition
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Funding
- Mangalore University
- UGC-SAP
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A series of 1,3,5-triaryl-2-pyrazolines 2a-g were synthesized by the reaction of 4,4'-disubstituted chalcone with phenyl hydrazine. All these compounds were characterized by NMR, IR and mass spectral and single crystal XRD data. All the synthesized products were screened for their in vitro antimicrobial, analgesic and antioxidant properties. The docking studies were carried out for these compounds against the active site of methionyl-tRNA synthetase (metRS). Some of the tested compounds exhibited significant antimicrobial, analgesic, DPPH scavenging activities and molecular binding.
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