Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 21, Issue 11, Pages 3863-3875Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-011-9906-8
Keywords
4-Aminoantipyrine derivatives; Antimicrobial; Anticancer; QSAR
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A series of 4-(substituted benzylidene-amino)-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-ones (1-17) was synthesized and tested in vitro for its antimicrobial and anticancer potentials. The biological screening results indicated that compounds having m-chloro substituent on benzaldehyde portion showed antimicrobial potential, whereas compounds having chloro, methoxy, and hydroxyl groups showed anticancer potential. The quantitative structure activity relationship (QSAR) studies indicated the importance of topological parameter, valence first order molecular connectivity index in describing antifungal activity. The developed QSAR models, however, were statistically insignificant with reference to anticancer activity of the synthesized compounds.
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