Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 21, Issue 8, Pages 1861-1868Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-011-9703-4
Keywords
Chromone; Hydrazone; Cytotoxic; Cytochrome c
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Funding
- Medical University of Lodz [503/3-016-02/503-01, 503/3-015-02/503-01, 503/3-016-03/503-01]
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Reactions of chromone derivatives 1-4 with N-substituted hydrazines were described. Hydrazones (6, 7a, 8a-c, 9b-e, 10e, 11e, 12) were evaluated for cytotoxicity (MTT test) against HL-60 and NALM-6 leukemia cells. Phosphorohydrazone of 3-formylchromone 8a and hydrazone of 2-amino-3-chromone derivative 11e showed appreciable cytotoxicity. The cytotoxicity indices of 8a, 11e, and 12 were higher on drug-resistant HL-60 ADR cells in comparison to HL-60. Compounds 8a and 11e were tested for their ability to induce cytochrome c translocation from mitochondria to cytosol.
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