Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 21, Issue 11, Pages 3557-3567Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-011-9892-x
Keywords
Synthesis; Phosphodiestase4B (PDE4b) inhibitor; Quinazolindiones; Docking study
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In this study, a series of 3-butylquinazolinedione linked with different substituent to N1 of quinazoline nucleus have been synthesized. Some of the new final compounds tested in vitro for their inhibitory activity against phosphodiestrase 4B which is the enzyme responsible for the hydrolysis of cyclic adenosine mono phosphate, the second messenger involved in the regulation of important cell functions. Compound 7f (100%) showed inhibition better than rolipram (90%), while the other tested compounds showed moderate activity. Docking study has been done to rationalize the obtained biological results.
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