Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 21, Issue 11, Pages 3327-3335Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-011-9846-3
Keywords
Phosphodiesterase 4 (PDE4) inhibitors; Quinazolinone; Asthma; Synthesis
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In this study, a novel series of quinazolinone derivatives analogue to nitraquazone structure were synthesized. The compounds tested for their inhibitory activity against phosphodiesterase 4B revealed that compound 6d shows promising inhibitory activity comparable to that of Rolipram, whereas compounds 6a and 6c exhibited moderate inhibitory activity.
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