Antibacterial activity of aminals and hemiaminals of pyrazole and imidazole

Antibacterial activity of 1,1'-methylenedipyrazole (AM1), 1-hydroxymethylpyrazole (SAM1), 1,1'-methylenediimidazole (AM2), and 1-hydroxymethylimidazole (SAM2) has been tested against reference and clinical strains by both difusimetric and broth dilution methods. Overall, the minimal inhibitory concentrations of tested compounds ranged from 180 to 270 mu g/ml, while the minimal bactericidal concentrations were between 360 and 720 mu g/ml. Comparative assessment with phenol and formaldehyde shows that AM1, AM2, SAM1, and SAM2 have moderate to good antibacterial activity.