Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 21, Issue 2, Pages 185-191Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-010-9522-z
Keywords
Quinoline; 1,3,4-Thiadiazole; Cyclization; Anticancer activity; Antitubercular activity; SAR; c log P
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A series of 6,7,8-substituted thiosemicarbazones (2a-j) of 2-chloro-3-formyl-quinoline derivatives were cyclized to the title compounds (3a-j) using acetic anhydride. The structures of the final compounds (3a-j) were confirmed by elemental and spectral (IR, H-1 NMR and MS) analysis. Some of the title compounds have shown promising anticancer and antitubercular activities.
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