Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 20, Issue 6, Pages 732-737Publisher
SPRINGER
DOI: 10.1007/s00044-010-9381-7
Keywords
Friedlander reaction; SnO2 nanoparticles; Erythrocytes; HeLa; Vero cells
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Funding
- Department of Science and Technology, Government of India [SR/FTP/CS-99/2006]
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An efficient, practical, and eco-friendly method of preparation of 9-chloro-6,13-dihydro-7-phenyl-5H-indolo[3,2-c]-acridines (3a-c) is reported by Friedlander condensation of 2-amino-5-chlorobenzophenone 1 and active methylene compound 3,4-dihydro-2H-carbazol-1(9H)-ones (2a-c) in the presence of SnO2 nanoparticles under microwave irradiation. Indoloacridines, 3a-c, were screened for their in vitro hemolytic activity, on human erythrocytes and cytotoxicity, on HeLa and Vero cells.
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