Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 20, Issue 1, Pages 109-115Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-009-9279-4
Keywords
Thiophenol; Chalcones; Antimicrobial activity
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Funding
- Technical Research Council of Turkey [TUBITAK-106T103]
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A series of thiophenol adducts (3a-m) were prepared by addition of thiophenol to chalcones (1a-m) in the presence of a catalytic amount of KOt-Bu in solvent free conditions. In addition, the antibacterial and antifungal in vitro properties were tested against some human pathogenic microorganisms by employing the disk diffusion technique. A majority of compounds were remarkably active against several of the microorganisms. Compound 3i was determined to be the most active compound.
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