Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 21, Issue 1, Pages 27-37Publisher
BIRKHAUSER BOSTON INC
DOI: 10.1007/s00044-010-9489-9
Keywords
Pyridine; Nicotine; Epibatidine; Mecamylamine; Analgesic activity
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Funding
- University of Pune
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A series of new heterocyclic derivatives having a pyridine nucleus were synthesized. 4-(5-(2-Chlorophenyl)-4H-1,2,4-triazol-3-yl)pyridine (7c) and 4-(5-(2-Nitrophenyl)-4H-1,2,4-triazol-3-yl)pyridine (7d) presented the best analgesic profie of this series in hot-plate, tail-flick, and formalin-induced licking tests, which was partially prevented by pretreatment with mecamylamine, a nicotinic receptor antagonist.
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