Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 20, Issue 8, Pages 1394-1401Publisher
BIRKHAUSER BOSTON INC
DOI: 10.1007/s00044-010-9490-3
Keywords
Antimicrobial activity; Structural activity relationship; SQ109; 1,2-Diamine
Categories
Funding
- National Research Foundation
- Gun [2046819]
- Aspen Pharmacare
- University of KwaZulu-Natal
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The antimicrobial activity of five novel SQ109 derivatives including SQ109 against bacteria, yeast and filamentous fungi is reported herein. Using broth microdilution techniques, compounds 2 and 3 were found to be active against most tested fungi and bacteria, with minimum inhibitory concentrations (MICs) ranging from 0.98 to 31 mu g ml(-1), except for Klebsiella pneumonia where the MIC was 250 mu g ml(-1). SQ109 and derivative 4 did not show any significant activity against most of the organisms used. However, their reduced derivatives 1 and 5 showed promising activity with MICs between 0.49 and 62.5 mu g ml(-1) against most of the microorganisms used.
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