Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 19, Issue 9, Pages 1203-1209Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-009-9263-z
Keywords
Gas chromatography-mass spectroscopy; Essential oil; Magnolia; Antioxidant; Gastric cencer; sCD40L; Phosphorylate-activate Akt protein
Categories
Funding
- National Natural Science Foundation of China [30872943]
- Social development projects of Suzhou [SS0711]
- Postgraduate innovative plan project of Jiangsu Province in 2009 [CX09B-033Z]
Ask authors/readers for more resources
The chemical composition of essential oil from magnolia collected in Suzhou city, China, was studied using gas chromatography-mass spectroscopy. Fifty-four volatile compounds were identified in the essential oil, with eucalyptol (21.55%), beta-Pinene(11.07%), D-Limonene (8.93%), 1R-alpha-Pinene (7.86%), Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1R)-(6.46%), Cyclohexene, 4-methylene-1-(1-methylethyl)- (5.30%), 1,4-Cyclohexadiene, 1-methyl-4-(1-methylethyl)- (5.10%), camphene (4.72%), being the major chemical constituents. In an in vivo approach, the protective effect of the essential oil against oxidative stress in gastric cancer (GC) mice was also investigated in terms of superoxide dismutase, CAT, and glutathione peroxidase activities. Our results indicate that the essential oil has an effective capability to enhance serum antioxidant enzyme activities and sCD40L, and decrease phosphorylate-activate Akt protein levels in a dose-dependent manner in gastric cencer mice. Overall, essential oil from magnolia appears to be an effective antioxidant and is quite suitable for further biological evaluation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available