Journal
MEDICINAL CHEMISTRY
Volume 9, Issue 2, Pages 203-212Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1573406411309020005
Keywords
Quantitative structure-activity relationship; Tyrosine kinase inhibitors; Lck inhibitors; Endothelial growth factor receptor (EGFR); 4-alkynylquinazolines; 4-alkenylquinazolines; N-4,6-pyrimidine-N-alkyl-N -phenyl ureas
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A quantitative structure-activity relationship (QSAR) study has been made on two different series of anticancer tyrosine kinase inhibitors, namely a series of 4-alkynyl and 4-alkenyl-quinazolines and a series of N-4,6-pyrimidine-N-alkyl-N'-phenyl ureas. For the first series, QSAR results indicate that the activity is controlled by the hydrophobicity of the molecules and molecular connectivity index of the substituent, whereas for the second series of compounds the activity is found to be controlled by the molecular connectivity index of the substituent and some indicator variables.
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