Journal
MEDICINAL CHEMISTRY
Volume 7, Issue 6, Pages 534-542Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157340611797928271
Keywords
2-Azetidinones; cholesterol absorption inhibitor; synthesis; bioactivities
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Funding
- Jiangsu Graduate Student Innovation Foundation [xm04-74]
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Twenty-four 2-azetidinone derivatives have been designed and synthesized as cholesterol absorption inhibitors. All new compounds were evaluated for their activity to inhibit cholesterol absorption in hamsters, and most of them showed considerable effects in lowering the levels of total cholesterol in the serum, especially compound 2d, 4a, 4f, 4i and 4j.
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