Journal
MEDICAL PHYSICS
Volume 41, Issue 12, Pages -Publisher
WILEY
DOI: 10.1118/1.4898202
Keywords
DCE-MRI; pharmacokinetic; dynamic perfusion; contrast agent; arterial input function
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Purpose: To present a review of most commonly used techniques to analyze dynamic contrastenhanced magnetic resonance imaging (DCE-MRI), discusses their strengths and weaknesses, and outlines recent clinical applications of findings from these approaches. Methods: DCE-MRI allows for noninvasive quantitative analysis of contrast agent (CA) transient in soft tissues. Thus, it is an important and well-established tool to reveal microvasculature and perfusion in various clinical applications. In the last three decades, a host of nonparametric and parametric models and methods have been developed in order to quantify the CA's perfusion into tissue and estimate perfusion-related parameters (indexes) from signal-or concentration-time curves. These indexes are widely used in various clinical applications for the detection, characterization, and therapy monitoring of different diseases. Results: Promising theoretical findings and experimental results for the reviewed models and techniques in a variety of clinical applications suggest that DCE-MRI is a clinically relevant imaging modality, which can be used for early diagnosis of different diseases, such as breast and prostate cancer, renal rejection, and liver tumors. Conclusions: Both nonparametric and parametric approaches for DCE-MRI analysis possess the ability to quantify tissue perfusion. (C) 2014 American Association of Physicists in Medicine.
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