Journal
MEDICAL PHYSICS
Volume 39, Issue 7, Pages 4155-4166Publisher
WILEY
DOI: 10.1118/1.4725710
Keywords
portal dosimetry; small animal micro-IR; Monte Carlo
Funding
- Marie Curie Grant [PIRG03-GA-2008-230911]
- ZonMW [40-00506-98-9019]
- GROW research institute
- CRISP, Centre for Research Innovation, Support and Policy of Maastricht University
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- NSERC
- O'Brien Foundation (New-Brunswick, Canada)
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Purpose: Novel small animal precision microirradiators (micro-IR) are becoming available for preclinical use and are often equipped with onboard imaging (OBI) devices. We investigated the use of OBI as a means to infer the accuracy of the delivered treatment plan. Methods: Monte Carlo modeling of the micro-IR including an elliptical Gaussian electron beam incident on the x-ray tube was used to score dose and to continue photon transport to the plane of the OBI device. A model of the OBI detector response was used to generate simulated onboard images. Experimental OBI was performed at 225 kVp, gain/offset and scatter-glare were corrected. Simulated and experimentally obtained onboard images of phantoms and a mouse specimen were compared for a range of photon beam sizes from 2.5 cm down to 0.1 cm. Results: Simulated OBI can be used in small animal radiotherapy to determine if a treatment plan was delivered according to the prescription within an uncertainty of 5% for beams as small as 4 mm in diameter. For collimated beams smaller than 4 mm, beam profile differences remain primarily in the penumbra region of the smallest beams, which may be tolerable for specific preclinical micro-IR investigations. Conclusions: Comparing simulated to acquired OBI during small animal treatment radiotherapy represents a useful treatment delivery tool. (C) 2012 American Association of Physicists in Medicine. [http://dx.doi.org/10.1118/1.4725710]
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