Journal
RHEUMATOLOGY
Volume 55, Issue 4, Pages 599-606Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/kev330
Keywords
rheumatoid arthritis; histopathology; spondyloarthritis; synovium; inflammation; microarrays; gene expression profiling; transcriptome; spondylarthropathies; cytokines and inflammatory mediators; fibroblasts; lymphocytes; macrophages
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Funding
- ReumaFonds [LLP-2] Funding Source: researchfish
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Increased knowledge about pathological processes active in inflammatory joint diseases is needed to initiate personalized medicine based on targeted treatments in the future. The molecular and cellular pathways that are active during joint inflammation may differ between the various inflammatory joint diseases, between different patient subgroups within one disease, or even between different stages of the disease in a single patient. In this review, we evaluate synovial inflammation in terms of descriptive histopathology through to more functional studies on human synovial tissue inflammation in RA and SpA, in phenotypic subgroups of RA and SpA patients, and during the disease course of both diseases.
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