Journal
MEDICAL ONCOLOGY
Volume 30, Issue 2, Pages -Publisher
HUMANA PRESS INC
DOI: 10.1007/s12032-013-0549-0
Keywords
miR-215; Colorectal cancer; Relapse; 5-FU; Adjuvant chemotherapy
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Funding
- National Natural Science Foundation of China [81172110]
- National High Technology Research and Development Program [2006AA 02A 402-B02, 2012AA 02A 504]
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To investigate the role of miR-215 in the relapse following radical surgery of colorectal cancer patients. The clinical data and surgical frozen tumor tissues were retrospectively collected from 125 stage II/III colorectal cancer patients, which contained 60 patients who relapsed and 65 patients who did not relapse within 3 years after surgery. The expression of miR-215 was determined by real-time PCR, and the relationship between miR-215 expression and the relapse was analyzed statistically. miR-215 was downregulated in relapsed patients compared to nonrelapsed patients (P = 0.001). The low expression of miR-215 was significantly correlated with a high probability of 3-year relapse (P = 0.001), which was more obvious in stage III patients P < 0.001). The multivariate analysis showed that miR-215 expression could function as an independent predictive marker for relapse. It seemed that patients with high expressions of miR-215 could benefit from 5-fluorouracilcontaining adjuvant chemotherapy without significant difference, whereas this phenomenon was reverse in patients with low expressions of miR-215. Our study highlighted for the first time that miR-215 could function as a potential predictive marker for relapse following radical surgery of colorectal cancer, and the possible correlation between miR215 and 5-fluorouracil-containing adjuvant chemotherapy would be validated in the future.
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