Journal
MEDICAL ONCOLOGY
Volume 29, Issue 3, Pages 1780-1788Publisher
HUMANA PRESS INC
DOI: 10.1007/s12032-011-0037-3
Keywords
Colorectal cancer; Immunohistochemistry; Tissue microarray; Prognosis; Heat shock protein 27 (HSP27); Heterogeneous nuclear ribonucleoprotein K (hnRNP K)
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Funding
- Shanghai JiaoTong University School of Medicine [BXJ201137]
- Major Basic Research Program of Shanghai [07DZ19505]
- National 973 Basic Research Program of China [2008CB517403]
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The present study was aimed at evaluating the expression of heat shock protein 27 (HSP27) and heterogeneous nuclear ribonucleoprotein K (hnRNP K), two potential biomarkers of many cancers, in colorectal cancer (CRC) and their clinical significance. Expression of HSP27 and hnRNP K were investigated by immunohistochemistry (IHC) in a series of tissue microarrays containing 175 primary colorectal cancers and their corresponding normal mucosa samples and matched with clinicopathological features and patient survival. HSP27 and hnRNP K displayed more frequent strong immunoreactivity in primary colorectal tumor samples compared with adjacent noncancer tissue (P<0.001). Increased cytoplasmic expression of HSP27 and hnRNP K were associated with tumor location (P = 0.032 and P<0.001, respectively), poorer overall survival (P = 0.004 and P = 0.02, respectively) and to an unfavorable prognosis for CRC patients in multivariate analysis (P = 0.019 and P = 0.01, respectively). Their overexpression combination identified a subset of patients with definitively worse prognosis than any other combination (P<0.001). Overexpression of HSP27 and hnRNPK were independent markers of poor prognosis, and their combination predicted definitively adverse outcomes in CRC patients.
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