Journal
MEDICAL ONCOLOGY
Volume 28, Issue 3, Pages 682-688Publisher
HUMANA PRESS INC
DOI: 10.1007/s12032-010-9515-2
Keywords
NSCLC; Dendritic cells (DC); Programmed-death receptor ligands 1 (PD-L1); CD83; CD1 alpha
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Funding
- National Natural Science Foundation of China [30770947]
- 135 Projects focus on Talent Foundation of Health Department of Jiangsu Province [RC2007075]
- Medical Development Foundation of Jiangsu Province [H200712]
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The immunohistochemical analysis was used to evaluate the expression of PD-L1 in 109 non-small cell lung cancer (NSCLC) tissues and para-tumor tissues. Associations between expressed PD-L1 and tumor histological types, degree of differentiation, and lymph node metastasis were calculated, and overall survival was assessed. Meanwhile, immunohistochemistry and immunofluorescence double labeling technique were performed to detect the expressions of PD-L1, CD1 alpha, and CD83 on TIDC of 20 lung cancer tissues, and the expression of PD-L1 in CD1 alpha(+)DCs and CD83(+)DCs and their significances were also explored. We found that the expression rate of PD-L1 in NSCLC was associated with histological types and overall survival. Patients with either adenocarcinoma or survival time after surgery less than 3 years showed higher expression rate of PD-L1. Furthermore, Cox model analysis indicated that PD-L1 might be regarded as a poor prognostic factor. PD-L1 could be also detected in CD1 alpha(+) immature DC in NSCLC, indicating that as a class of key anti-tumor immunocyte in tumor microenvironment, DC expressing PD-L1 itself might play an important role in keeping its immature status and contributing to tumor cells immune escape and disease progression.
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