Journal
MEDICAL ONCOLOGY
Volume 29, Issue 1, Pages 77-83Publisher
HUMANA PRESS INC
DOI: 10.1007/s12032-010-9766-y
Keywords
Microarray; Gastric cancer; Marker; Enrichment; Prognosis
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Funding
- Fundamental Key Science Foundation of Science and Technology Commission of Shanghai Municipality [09JC1412400, 10411967300]
- Public Scientific Research Platform of Hospital of Grade A at the Tertiary Level of Shanghai [SHDC12007704]
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Expression microarrays are widely used for investigating the candidate molecular targets in human cancer. While genome-wide expression signatures screened by gene set enrichment analysis (GSEA) were not performed in Chinese gastric cancer (GC). To gain new molecular targets for GC, GSEA analysis was performed. In the present study, GSEA were used to pick out differentially expressed gene sets of our database. Total RNA of paired tissue samples (n = 48) and a tissue microarray containing 132 paired tissues were used to further validate expression levels of INHBA and its correction with clinicopathological factors. Upregulated INHBA expression in gastric cancer was screened and further confirmed by qPCR and immunostaining analysis. Increased INHBA expression was significantly correlated with the diameter of cancer and depth of tumor invasion. Patients with higher expression levels of INHBA had a shorter disease-free survival rate. It was effective to gain new molecular targets for GC by GSEA analysis. INHBA may be a poor survival indicator of GC.
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