Journal
MEDICAL ONCOLOGY
Volume 27, Issue 3, Pages 685-689Publisher
HUMANA PRESS INC
DOI: 10.1007/s12032-009-9269-x
Keywords
MicroRNA-31; Gastric cancer; Gene expression; Gene diagnosis
Categories
Funding
- Zhejiang Provincial Education Department [20070965]
- Ningbo University [Cxxkf 2008-067]
- Ningbo Natural Science Foundation [2009A610134]
- Zhejiang Province Research Project [2008C33020, 2008F70052]
- Zhejiang Natural Sciences Foundation [Y207240, Y207244]
- National Natural Science Foundation of China [30872420]
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MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-31 in gastric cancers are unclear. The objective of the present study was to compare the expression profile of miR-31 between gastric cancer tissues and non-tumor tissues. Real-time quantitative reverse transcription-polymerase chain reaction technology was used to detect the levels of miR-31 expression. The expression levels of miR-31 in gastric cancer tissues were significantly lower than those in non-tumor tissues. This new information may help to clarify the molecular mechanisms involved in gastric carcinogenesis and to indicate that miR-31 may be a novel diagnostic biomarker of gastric cancer.
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