Journal
MEDICAL ONCOLOGY
Volume 25, Issue 4, Pages 374-379Publisher
HUMANA PRESS INC
DOI: 10.1007/s12032-008-9049-z
Keywords
Rituximab; Maturation arrest; Neutropenia; Lymphoma; HAX1; Granulopoiesis
Categories
Funding
- Swedish Society for Medical Research
- Swedish Cancer Foundation
- Roche Pharmaceutical
- Stockholm County Council
Ask authors/readers for more resources
Late-onset neutropenia, i.e. an absolute neutrophil count of < 1.5 x 109/l, may follow 4 weeks or more after therapy with rituximab for lymphoma. However, incidence, predisposing factors, and pathogenic mechanisms are still poorly defined. In a retrospective study of 113 consecutive lymphoma patients treated with rituximab, with or without chemotherapy, we found eight patients (7%) with late-onset neutropenia (LON). Median time to onset was 88 days (range, 1-9 months) after last rituximab dose. Median duration of LON was 54 days (range, 1-17 weeks). Four of the eight patients underwent stem cell transplantation. Three patients developed febrile neutropenia and two required treatment with granulocyte colony-stimulating factor. In four subsequently identified patients with severe LON, a maturation arrest at the (pro)myelocyte stage was observed in the bone marrow, similar to that found in severe congenital neutropenia or Kostmann disease. However, none carried mutations in HAX1, thus ruling out such mutations in the development of the maturation arrest in these patients. Nevertheless, our data suggest that rituximab-related LON and congenital neutropenia might share similar neutropenia-causing mechanisms resulting in maturation arrest.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available