Journal
MEDICAL MYCOLOGY
Volume 49, Issue 4, Pages 352-355Publisher
OXFORD UNIV PRESS
DOI: 10.3109/13693786.2010.530697
Keywords
primary cutaneous cryptococcosis; Cryptococcus gattii; immunocompetent host; fluconazole; VGII genotype
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This paper presents the case of a 75-year-old Brazilian man who developed inflammatory skin lesions with nodules and ulcerations on the right forearm after an injury caused by handling barbed-wire and Eucalyptus spp. logs. Histopathological assessment of the lesions showed granulomatous processes with yeasts similar to Cryptococcus spp. Tissue fragments yielded yeasts when cultured that were identified as Cryptococcus gattii VGII through biochemical reactions and URA 5-RFLP genotype. No evidence of systemic involvement or any underlying immunosuppressive diseases were identified, which supported the diagnosis of primary cutaneous cryptococcosis. After 5 months on therapy with high fluconazole doses, the skin lesions had fully healed.
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