Journal
MEDICAL MYCOLOGY
Volume 47, Issue -, Pages S331-S337Publisher
OXFORD UNIV PRESS
DOI: 10.1080/13693780802266777
Keywords
Aspergillus; cystic fibrosis; allergy
Categories
Funding
- National Institutes of Health [P50HL084932]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P50HL084932] Funding Source: NIH RePORTER
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Allergic bronchopulmonary aspergillosis (ABPA) is an allergic disease characterized clinically by wheezing, pulmonary infiltrates, bronchiectasis, and fibrosis that affects patients with asthma and cystic fibrosis (CF). Although this disease has been characterized by a Th2 immune response to Aspergillus, the disease has some features such as central bronchiectasis which is not seen in other Th2 driven lung diseases such as atopic asthma. Here we will review the current pathophysiology of ABPA in CF and highlight new molecules that may affect immune responses against Aspergillus and ABPA disease pathogenesis.
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