Journal
MEDICAL MYCOLOGY
Volume 47, Issue -, Pages S183-S191Publisher
OXFORD UNIV PRESS
DOI: 10.1080/13693780802189938
Keywords
Allergic bronchopulmonary aspergillosis (ABPA); aspergillus; cystic fibrosis (CF); chemokines; chemokine receptors; Th2; TARC; CCL17; CCL22; CCR4
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Allergic bronchopulmonary aspergillosis (ABPA), a pulmonary hypersensitivity disease mediated by an allergic response to Aspergillus fumigatus (A. fumigatus), occurs preferentially in disease conditions with an impaired pulmonary immunity, especially in cystic fibrosis (CF) and allergic asthma. The pathophysiological mechanisms underlying the link between CF and ABPA are poorly understood. Animal and human data support a critical role for chemokines, especially CCL17 and its receptor CCR4, in ABPA. A summary and discussion of the immunological mechanism involved in the pathogenesis of ABPA with a focus on CF lung disease and the role of chemokines is presented here.
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