Journal
MEDICAL MYCOLOGY
Volume 46, Issue 1, Pages 1-15Publisher
OXFORD UNIV PRESS
DOI: 10.1080/13693780701435317
Keywords
Candida albicans; gene family; glycoprotein; cell surface
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Funding
- NCRR NIH HHS [C06 RR016515, C06 RR16515-01] Funding Source: Medline
- NIDCR NIH HHS [R01 DE014158-13, DE14158, R01 DE014158] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [C06RR016515] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE014158] Funding Source: NIH RePORTER
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The agglutinin-like sequence (ALS) family of Candida albicans includes eight genes that encode large cell-surface glycoproteins. The high degree of sequence relatedness between the ALS genes and the tremendous allelic variability often present in the same C. albicans strain complicated definition and characterization of the gene family. The main hypothesis driving ALS family research is that the genes encode adhesins, primarily involved in host-pathogen interactions. Although adhesive function has been demonstrated for several Als proteins, the challenge of studying putative adhesins in a highly adhesive organism like C. albicans has led to varying ideas about how best to pursue such investigations, and results that are sometimes contradictory. Recent analysis of als/als strains suggested roles for Als proteins outside of adhesion to host surfaces, and a broader scope of Als protein function than commonly believed. The availability and use of experimental methodologies to study C. albicans at the genomic level, and the ALS family en masse, have advanced knowledge of these genes and emphasized their importance in C. albicans biology and pathogenesis.
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