Journal
MEDICAL MYCOLOGY
Volume 46, Issue 2, Pages 113-118Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13693780701651681
Keywords
Paracoccidioides brasiliensis; chemotherapy; Ajoene; Allium sativum; sulfamethoxazole/trimethoprim
Categories
Ask authors/readers for more resources
Ajoene has been described as an antithrombotic, anti-tumour, antifungal, antiparasitic and antibacterial agent. This study deals with the efficacy of ajoene to treat mice intratracheally infected with Paracoccidioides brasiliensis. The results indicate that ajoene therapy is effective in association with antifungal drugs (sulfametoxazol/trimethoprim), showing a positive additive effect. Ajoene-treated mice developed Th1-type cytokine responses producing higher levels of IFN-gamma and IL-12 when compared to the infected but untreated members of the control group. Antifungal activity of ajoene involves a direct effect on fungi and a protective pro-inflammatory immune response. Reduction of fungal load is additive to chemotherapy and therefore the combined treatment is mostly effective against experimental paracoccidioidomycosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available